Great bike, no doubt. Probably the biggest issue is that performing a valve inspection is a fairly big pain in the arse, partially due to the special tools needed to hold open the VTEC valves for inspection, and partially due to the difficulty in getting to the front cylinder heads (removing the forks helps a lot). This is due at around 26000 kms, which isn't that far into your future with that mileage, so read up on it at the VFRD site mentioned earlier. Oh, and bleeding the brake lines is a bit more involved due to the linked brake system. The bike can also suffer from Honda's typically weak Regulator/Rectifier (this plagues many of their bikes). Side mounted radiators are nice for avoiding stone dings and dents, but if you drop it or low-side it, they can get wrecked. If you choose to hunt down some frame sliders, shop carefully and read up on that VFRD site - there are no (to my knowledge) sliders out there that will actually do the job that do not involve drilling the plastic to get to a properly secure frame mounting point.
Also as mentioned, the stock exhaust is a bit sewing-machine sounding, so either gut them or get a set of Leo Vince cans - it really transforms the noise into something much more snarling without being excessively loud (they come with optional inserts to quiet it down if you choose). I also would recommend a Power Commander to smooth out what can be a bit of a jerky throttle response (Honda leans things out in a few spots for emissions reasons) and a fender eliminator for the back end - makes the bike look so much nicer. Here's some shots of mine with the LV exhaust.
It's not a light bike by any means, which you can certainly feel when moving it around by hand or at low speeds, but on the road that weight is really not noticeable and the bike handles very well with a predictable and neutral behaviour. Riding position is very comfortable, even with the stock seat.