For the longest time we donated to Riders for Health, a charity co-founded by ex-racer Randy Mamola with long-time links to the MotoGP paddock (since split off into Two Wheels for Life supporting Riders for Health, not sure why). They provide health care via motorcycle to parts of rural Africa that are difficult or expensive to reach with 4x4. It started when Mamola visited and saw nearly new bikes donated by Yamaha sitting broken down and realised there was no skills or infrastructure to maintain them, so the focus switched from free bikes to fleet management, supplying parts and providing training for mechanics.
That said, with the chaos in the world over the past couple years, we've switched most of our donations to Medecins Sans Frontieres, with some reserved for animal charities closer to home.
We also donate to our Anglican church, which inspires eye-rolls from many. But I've seen first hand how much help ours and other local churches provide for the local homeless, and how far those dollars go to making real impacts. Lots of churches do tons of work quietly, spending church funds to purchase the food and volunteer work from parishioners to prepare and distribute meals. I know it doesn't fit the smug narrative of those who like to write off all organised religion as greedy charlatans taking advantage of the simple-minded, but my first-hand experience has been the polar opposite of that. Not that that doesn't exist, but it's hardly universal...