They are both similar devices, some of the differences from what I got from garmins website:
Nuvi on the left, Zumo 220 in the right.
[TABLE="class: compare, width: 0"]
[TR="class: difference, bgcolor: #F0F0ED"]
[TD="align: left"]
Routes:[/TD]
[TD="class: prd27442, align: left"]10[/TD]
[TD="class: prd65210, align: left"]10 (additional storage on microSD™ card)[/TD]
[/TR]
[/TABLE]
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[TR="class: difference, bgcolor: #F0F0ED"]
[TD="align: left"]
Lane assist (guides to proper lane for navigation):[/TD]
[TD="class: prd27442, align: left"]no[/TD]
[TD="class: prd65210, align: left"]yes[/TD]
[/TR]
[/TABLE]
[TABLE="class: compare, width: 0"]
[TR="class: difference, bgcolor: #F0F0ED"]
[TD="align: left"]
Bluetooth® wireless technology:[/TD]
[TD="class: prd27442, align: left"]no[/TD]
[TD="class: prd65210, align: left"]yes (helmet or headset use only)[/TD]
[/TR]
[/TABLE]
[TABLE="class: compare, width: 0"]
[TR="class: difference, bgcolor: #F0F0ED"]
[TD="align: left"]
nüMaps Guarantee:[/TD]
[TD="class: prd27442, align: left"]
yes[/TD]
[TD="class: prd65210, align: left"]no[/TD]
[/TR]
[/TABLE]