Timely posting for me too - I'm heading off on September 20th to the general vicinity.  I stayed at Wytheville during a trip to S.C. and it is a beautiful area.  I don't even mind slabbing it on I-77 which is in terms of interstates one of the nicest I've been on.  My plan was to make Willville Bike Camp my first stop for a couple of days - and its only about another 1 1/2 hours down the road.  Looking at the website and my google maps to get there - it would actually work quite well as a base camp for exploring the area - 2 or 3 nights there - then continue down the BRP to the southern part - a couple of nights camping around Deals Gap, then work my way back via some areas I wanted to explore further in Kentucky.  
Having 9 days instead of 4 certainly opens a lot more options 
