We did most of those roads this year. All of it is really neat in different ways. Here are my comments:
Townsend to Gatlinburg (fighting creek road), runs right along the river. Very very pretty, but very difficult to pass. We were there in July, and you do nothing but sit behind people going 15 miles an hour under the speed limit. Not sure how busy it is late in the season. You need to be a confident passer on this road. The river it follows is fantastically beautiful. Well worth if you are not about speed.
Gatlinburg itself wasn't my cup of tea, much like niagra falls, very touristy. A bit cheasy, very busy. Although the free moonshine tasting was a lot of fun. Just make sure you don't over-indulge if you are riding.
The 441 south of gatlinburg is very nice pavement, and would make an awesome Isle of Mann type stage. Very hilly, great corners, but was nearly a traffic jam in the middle of July since its the main route for most people. You get stuck behind a bus and its game over. Again, very hard to pass, but worth it if you go early/late in the day.
Edit: The road even has a loop-de-loop in it. Best. Design. Ever.
Instead of going across the 19, go south at Cherokee on the 441. Check out the Notorious PIG for bbq. They are located at the Exxon station on the 441 Just south of Dillsboro. Worth the trip. He used to be at KillBoy's shack, but apparently that didn't work out. He has a facebook page listing hours and such. The north half of the 281 (Canada Rd) is one of the best pieces of road in the area. Very quiet, nice tight corners. If you are a track enthusiast, you will like it. Bring some race leathers if you want to ride it appropriately. The bottom half is tar and chip, but too slow/crappy to have a good time on. Make sure you have enough gas.
The south part of the 215, from the 64 to the Blue Ridge is like the Cheroholla, but quiet and a little tighter. There is a mountain climb section right before the BRP if you are riding northward that is sweet switchbacks all the way up the mountain. Nice road. The north part of the 215 (above the BRP) is brand new tar and chip. Very loose, very sketchy and frankly a waste of time. Cut back over the BRP and catch the 74.
The south 28 from Franklin all the way to Fontana Village IMO is the best section of road in the area. Stop by Cafe Rel (weird hours, and super busy so get there right when they open) for some excellent food.
The 64 south from Franklin to Highlands is also really nice, but a bit busier, locals dislike aggressive passing, so pass at your discretion. Some neat waterfalls to check out.
The Foothills parkway is a waste of time IMO, we often see cops there. Need too high of a speed over the limit to make it fun, so take it easy through there.
A bit off course, but we did Wayah Rd. this year. Pretty, but the tar and chip sucks. If you just like the scenery and don't mind a loose surface at spots its nice, but personally I wouldn't ride it again